Unfortunately, Piwik is not compatible with the Apache web server module
mod_security nor with CA SiteMinder. If your web host uses mod_security to block requests containing URLs (eg. hosts like HostGator, The Planet), you should contact your provider to have your Piwik application whitelisted and have mod_security disabled for Piwik.
With mod_security (or CA SiteMinder) is enabled Piwik will look like it works but these security modules create major bugs in Piwik, including major data loss as requests are mistakenly discarded by the server! For more information, see this ticket on Piwik issue tracker.
Some of the error messages you may see in Apache error log when using mod_security include
client denied by server configuration:. When the other tool CA Siteminder is enabled, you may get:
Due to the presence of characters known to be used in Cross Site Scripting attacks, access is forbidden. This web site does not allow Urls which might include embedded HTML tags..